Avirulent mutants of rabies virus and their use as live vaccine.
Identifieur interne : 000379 ( France/Analysis ); précédent : 000378; suivant : 000380Avirulent mutants of rabies virus and their use as live vaccine.
Auteurs : A. Flamand [France] ; P. Coulon ; F. Lafay ; C. TuffereauSource :
- Trends in microbiology [ 0966-842X ] ; 1993.
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Rabies Vaccines, Vaccines, Attenuated.
- chemical , toxicity : Glycoproteins.
- geographic : Europe.
- genetics : Rabies virus.
- Animals, Animals, Wild, Mutation, Vaccination, Virulence.
Abstract
Oral vaccination of foxes against rabies began in Switzerland some 20 years ago and was later extended to several European countries. The vaccine strains, which were derivatives of the SAD strain of rabies, retain a non-negligible pathogenicity for rodents and nontarget species. Antigenic mutants of the SAD Bern vaccine strain, which are avirulent for adult mice, foxes and dogs, have been isolated and are presently under trial.
PubMed: 8162418
Affiliations:
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pubmed:8162418Le document en format XML
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Flamand</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire de Génétique des Virus, CNRS, 91198 Gif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Génétique des Virus, CNRS, 91198 Gif</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif</settlement></placeName></affiliation></author><author><name sortKey="Coulon, P" sort="Coulon, P" uniqKey="Coulon P" first="P" last="Coulon">P. Coulon</name></author><author><name sortKey="Lafay, F" sort="Lafay, F" uniqKey="Lafay F" first="F" last="Lafay">F. Lafay</name></author><author><name sortKey="Tuffereau, C" sort="Tuffereau, C" uniqKey="Tuffereau C" first="C" last="Tuffereau">C. Tuffereau</name></author></analytic><series><title level="j">Trends in microbiology</title><idno type="ISSN">0966-842X</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Animals, Wild</term><term>Europe</term><term>Glycoproteins (toxicity)</term><term>Mutation</term><term>Rabies Vaccines (immunology)</term><term>Rabies virus (genetics)</term><term>Vaccination</term><term>Vaccines, Attenuated (immunology)</term><term>Virulence</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Rabies Vaccines</term><term>Vaccines, Attenuated</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Glycoproteins</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Rabies virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Wild</term><term>Mutation</term><term>Vaccination</term><term>Virulence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Oral vaccination of foxes against rabies began in Switzerland some 20 years ago and was later extended to several European countries. The vaccine strains, which were derivatives of the SAD strain of rabies, retain a non-negligible pathogenicity for rodents and nontarget species. Antigenic mutants of the SAD Bern vaccine strain, which are avirulent for adult mice, foxes and dogs, have been isolated and are presently under trial.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Gif</li></settlement></list><tree><noCountry><name sortKey="Coulon, P" sort="Coulon, P" uniqKey="Coulon P" first="P" last="Coulon">P. Coulon</name><name sortKey="Lafay, F" sort="Lafay, F" uniqKey="Lafay F" first="F" last="Lafay">F. Lafay</name><name sortKey="Tuffereau, C" sort="Tuffereau, C" uniqKey="Tuffereau C" first="C" last="Tuffereau">C. Tuffereau</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Flamand, A" sort="Flamand, A" uniqKey="Flamand A" first="A" last="Flamand">A. 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